Leukoplakia is considered has the most common premalignant lesion. The estimated prevalence rate of leukoplakia is 2% worldwideThose lesions present particularly in the floor of the mouth, tongue, lip and vermilion have a high risk of malignant potential.

Five Clinical Criteria Demonstrate a Particularly High Risk of Malignant Change

• The high risk is considered to be the verrucous type

• If the lesion is associated with erosion or ulceration then, the lesion is suggested to have high malignant potential

• The presence of a nodule in the lesion indicates higher malignant potential

• A lesion that is hard and indurative in its periphery is predictive of malignant change

• Oral leukoplakia seen in the anterior floor of the mouth and undersurface of the tongue is strongly linked to malignant potential.

Treatment: It consists of cessation of smoking or other tobacco related products

Also treatment with laser , cryoablation can be done to eradicate leukoplakia